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Piero Hincapié looks set to miss Arsenal's FA Cup quarterfinal against Southampton after picking up an injury while on international duty.
The left-back traveled to Spain for Ecuador's friendly against Morocco on March 27, but was substituted late in the match after suffering a hamstring problem.
Hincapié then sat out Ecuador's fixture against the Netherlands, and The Athletic have since confirmed that he will be unavailable for the trip to Southampton this weekend due to the injury.
Mikel Arteta declined to give a specific timeframe for the 24-year-old's recovery when speaking to reporters on Friday, and Hincapié's unavailability represents a significant setback for Arsenal heading into a pivotal week.
The Gunners follow up their trip to the south coast with a visit to Sporting CP in the first leg of their Champions League quarterfinal on Tuesday, before hosting Bournemouth at the Emirates Stadium in the Premier League.
On a brighter note for Arteta, several players could be returning from injury in time for Saturday's match.
Ødegaard, Timber Could Provide Welcome Boost
Arteta offered encouraging injury news on a number of players ahead of the Southampton fixture, stating that captain Martin Ødegaard and first-choice right back Jurriën Timber are "in contention to possibly be in the squad."
Both players sat out the international break following their absences from the Carabao Cup final loss to Manchester City, but their potential returns would be a significant lift for Arteta's side.
Ødegaard has been absent since the north London derby demolition of Tottenham Hotspur in February and will be especially vital in the weeks ahead given that Eberechi Eze remains sidelined for the foreseeable future.
Timber is expected to reclaim his spot from Ben White in the starting eleven once fully fit, adding further depth to what is already the Premier League's most formidable defense.
Noni Madueke was another player to suffer during the international break, picking up a concerning-looking knee injury during England's friendly draw with Uruguay. However, Arteta has since confirmed the problem is less serious than initially feared.
"No, it's not [serious]," Arteta said of Madueke's injury. "It looked really bad, Noni was really worried especially after what happened to him in his other knee a few weeks ago.
"He was out for six weeks [last time], but no, he's nowhere near that injury, so that's really good news."