Real Madrid Take On RB Leipzig: What To Expect, Bold Predictions, and Starting Lineups Revealed

Yan Diomande's imminent reunion with his former RB Leipzig teammates is the standout storyline heading into Real Madrid's third Champions League fixture of the campaign.

The 19-year-old gave the Bernabéu faithful plenty to cheer about on Sunday with his first truly impressive display since his record-setting move this summer, contributing a spectacular goal and assist in the 4–1 triumph over Sevilla.

The bar has been raised for Diomande, who now gears up to face the club where he built his reputation last season. He could be partnered in attack by Vinícius Júnior—another hot topic of late, with the Brazilian cleared to play in the Champions League despite serving a four-match domestic suspension.

Madrid can secure three consecutive European victories with a win against Leipzig, though supporters will likely hope for a more comfortable affair than the—admittedly entertaining—4–3 thriller against Roma in their previous outing.

Another high-scoring evening looks entirely possible either way; Leipzig conceded four away at Como in their Champions League opener and were hammered by Bayern Munich over the weekend. They have also recorded victories by three or more goals on three separate occasions already in 2026–27.

Real Madrid vs. RB Leipzig Score Prediction

Los Blancos Overwhelm Visitors

This match arrives just four days before the opening Clásico of the season and, very possibly, the fixture that will determine whether Real Madrid are genuine title contenders. You could hardly blame José Mourinho for having one eye on what lies ahead.

In Leipzig, his Madrid side face a team of stark contrasts—one capable of dismantling the likes of Frankfurt (6–0) and Hamburg (5–0), yet also susceptible to heavy losses against Bayern (6–1) and Como (4–1).

Madrid cannot afford to switch off, and Martín Demichelis's outfit are undeniably a threat. However, their expansive, attack-minded approach has repeatedly left them exposed on the road, and Madrid's star-studded forward line will have no shortage of opportunities.

Prediction: Real Madrid 3–0 RB Leipzig

Real Madrid Predicted Lineup vs. RB Leipzig

Madrid's squad availability is as strong as it has been all season, with only long-term injury absentees Ferland Mendy, Rodrygo, and Raúl Asencio expected to sit this one out.

Diomande could line up against his former club from the right flank of Madrid's attack, rather than the left—as was the case against Sevilla at the weekend—with Vinícius Jr once again an option for Mourinho.

The manager's primary concern will be ensuring his squad comes through the night unscathed and with enough energy in reserve, given the trip to Barcelona is now just around the corner.

Real Madrid predicted lineup vs. RB Leipzig (4-2-3-1): Courtois; Alexander-Arnold, Konaté, Huijsen, Carreras; Valverde, Tchouaméni; Diomande, Bellingham, Vinícius Jr; Mbappé.

RB Leipzig Predicted Lineup vs. Real Madrid

Marc Guiu and Assan Ouédraogo are both sidelined through injury. Attacking midfielder Christoph Baumgartner also missed the weekend defeat to Bayern and remains a doubt to feature from the start on Wednesday.

Brazilian forward Rômulo is expected to reclaim his place leading the attack after being left on the bench at the weekend. Top scorer Christopher Nkunku may consequently drop into a deeper position.

Norway international Antonio Nusa and loanee Brajan Gruda offer a threat from wide areas and will likely look to exploit the space left behind Madrid's own attacking wingers on the counter.

RB Leipzig predicted lineup vs. Real Madrid (4-2-3-1): Vandervoordt; Baku, Orbán, Lukeba, Raum; Banzuzi, El Aynaoui; Nusa, Nkunku, Gruda; Rômulo.

What Time Does Real Madrid vs. RB Leipzig Kick Off?

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