Old Trafford plays host to the revival of one of England's most intense rivalries this Sunday, as Liverpool travel to face Manchester United in the Premier League.
The stakes feel somewhat diminished compared to what they might have been a few weeks ago, with both clubs now virtually assured of Champions League football through a top-five finish by season's end. Nevertheless, bragging rights remain the ultimate prize this weekend.
Man Utd currently hold the upper hand after their 2–1 victory at Anfield back in October, though Liverpool claimed the spoils on their last visit to Old Trafford—Arne Slot's first experience of this fixture produced a commanding 3–0 triumph last season.
Sunday's meeting is delicately balanced with just three points splitting the two sides, and a moment of individual genius could settle this historic fixture's 246th chapter.
Here are three key matchups that could prove decisive in Manchester.
Bruno Fernandes vs. Ryan Gravenberch

Ryan Gravenberch claimed last season's Premier League Young Player of the Season award, yet it is Bruno Fernandes who looks increasingly likely to be recognised this campaign. Following his 19th assist of the season in Monday's victory over Brentford—just one shy of the all-time single-season divisional record—United's captain has emerged as the leading contender for the league's Player of the Season award for 2025–26.
Few could dispute the honour given his remarkable performances through adversity for the Red Devils. Beyond his staggering assist tally, he has contributed eight Premier League goals alongside a league-leading 114 chances created—nearly twice as many as the next most creative player in the division. Neutralise Fernandes and you've already won half the battle.
That thankless task falls to Gravenberch this weekend, with support from Alexis Mac Allister in Liverpool's double pivot. The Dutchman has operated below last season's exceptional standards, yet has remained one of his team's more dependable performers—no small feat given Liverpool's turbulent campaign.
Containing Fernandes proved beyond Gravenberch in the reverse fixture at Anfield. Substituted after an hour on a difficult afternoon for the midfielder, he was powerless to stop United's skipper from weaving his magic. Fernandes created three chances, registered an assist, and completed 12 passes into the final third.
Gravenberch has the opportunity to make amends this weekend.
Dominik Szoboszlai vs. Casemiro

Where would Liverpool be without Dominik Szoboszlai this season? The short answer: in serious difficulty.
Unquestionably Liverpool's most influential player this term—and the recipient of five of the club's eight Player of the Month honours—Szoboszlai has been the driving force behind his side's finest displays. Much like Fernandes, he so frequently provides the spark when those around him are below par.
With 12 goals and nine assists across all competitions this season, Szoboszlai has been Liverpool's primary creative outlet, and Slot will lean heavily on his ingenuity at Old Trafford. With Hugo Ekitiké sidelined through injury and Mohamed Salah also absent, even greater attacking responsibility rests on the Hungarian's capable shoulders.
The challenge for Szoboszlai this weekend will be his designated marker. In what could be one of his final home appearances for United, Casemiro will be tasked with keeping Liverpool's No. 8 quiet.
Casemiro has frequently drawn praise for his attacking contributions this season, chipping in with timely interventions in the final third, but the cornerstone of his revival has been a return to his commanding best in a defensive capacity.
Kobbie Mainoo's reintegration into the side has freed Casemiro to concentrate on his defensive responsibilities, and few opponents have been able to bypass his vast experience and tactical awareness in recent months. Szoboszlai will be the next to test him.
Alexander Isak vs. Harry Maguire

A torrid debut season for Premier League record signing Alexander Isak is nearing its conclusion. A combination of unrealistic expectations and injury setbacks has hampered the Swede's impact, though there remains time for a late flourish to close the campaign on a positive note. Having netted his fourth Liverpool goal in last weekend's win over Crystal Palace, he has a handful of opportunities left to make his mark.
A standout display at Old Trafford would certainly provide Isak with some much-needed vindication. While the former Newcastle United forward carries a modest record in previous meetings with United—just one goal in nine outings—a well-timed confidence boost could serve him well heading into Sunday's contest.
Harry Maguire, the match-winner in October's encounter, returned from suspension against Brentford, yet United still appeared vulnerable defensively. Igor Thiago was wasteful in front of goal at Old Trafford, but he made life extremely difficult for Maguire and his defensive colleagues. He is not the first powerful centre-forward to manage that, with Dominic Calvert-Lewin also causing havoc during Leeds United's recent Old Trafford triumph.
Should Isak replicate Thiago and Calvert-Lewin's approach and add a clinical finish, he would go a long way towards winning over the Liverpool faithful.
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